ACZONE ® (dapsone) GEL, 7.5% IMPORTANT INFORMATION APPROVED USE. ACZONE ® (dapsone) Gel, 7.5% is a prescription medicine used on the skin (topical) to treat acne in people 12 years and older. Contains Nonbinding Re commendations Draft Guidance on Dapsone. Recommended Dec 2014; Revised Oct 2017, Nov 2018. This draft guidance, when finalized, will represent the current thinking of the. Commonly used topical acne therapies include BP, salicylic acid, antibiotics, combination antibiotics with BP, retinoids, retinoid with BP, retinoid with antibiotic, azelaic acid, and sulfone agents. Aczone (dapsone) is an anti-infective medication. Aczone is a topical gel used to help treat acne. The mechanism of action of in treating acne is not known. Contraindications to dapsone. Dapsone should not be taken by anyone that is allergic to dapsone. Some patients with sensitivity to other sulphone antibiotics can tolerate dapsone. User Reviews for Aczone to treat Acne. The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care. As alternatives to first-line regimens, the HIV treatment guidelines recommend dapsone 100 mg PO once daily. Alternatively, dapsone 50 mg PO once daily can be given in combination with weekly pyrimethamine (50 mg PO) plus leucovorin (25 mg PO) OR as a weekly regimen of 200 mg PO plus pyrimethamine (75 mg PO) and leucovorin (25 mg PO). ACZONE (dapsone) Gel, 7.5%, contains dapsone, a sulfone, in an aqueous gel base for topical dermatologic use. ACZONE Gel, 7.5% is an off-white to yellow gel with suspended particles. Chemically, dapsone has an empirical formula of C 12 H 12 N 2 O 2 S. It is a white or slightly yellow-white Dapsone, also known as diaminodiphenyl sulfone (DDS), is an antibiotic commonly used in combination with rifampicin and clofazimine for the treatment of leprosy. It is a second-line medication for the treatment and prevention of pneumocystis pneumonia and for the prevention of toxoplasmosis in those who have poor immune function. Additionally. Dosage and Administration Administration. Dapsone is applied topically to the skin as a 5% gel. Dapsone topical gel is for external use only. The gel should not be used orally or intravaginally and contact with the mouth and eyes should be avoided.